Elucidation of Regional Mechanical Properties of Brain Tissues Based on Cell Density

Abstract Research on the mechanical properties of brain tissue has received extensive attention. However, most current studies have been conducted at phenomenological level. In this study, indentation method was used to explore difference in local among different regions porcine cerebral cortex. Further, hematoxylin-eosin and immunofluorescence staining methods were determine correlation between cellular density test points The frontal lobe exhibited strongest viscosity. temporal displayed lowest sensitivity changes speed, occipital highest shear modulus. Additionally, modulus areas cortex negatively correlated with total number cells per unit area positively neuronal cell bodies area. Exploration can provide basic data for establishment a finite element model referential information implantation position chips.